A Novel Way to Control Blood Pressure

Researchers from the King’s College in London have found a novel method of regulating blood pressure. According to their report published in the journal Science, the finding might pave the path for development of new medications for combating strokes and heart attacks.

High blood pressure affects one in every four adults. There are already powerful medications available for treating the condition; however very few people manage to achieve blood pressure levels as per medical guidelines.

Researchers led by Dr. Philip Eaton found that it is possible to regulate the protein Kinase G (PKG) independently of nitric oxide to bring blood pressure under control. PKG has an important role to play in all tissues in the body; however its fundamental role is in regulation of blood pressure in the cardiovascular system.

PKG requires the presence of nitric oxide, which is produced within blood vessels, in order to be able to regulate of blood pressure. The process involved in this regulation is known as oxidation. So far, research has found oxidation to be harmful for the body rather than helpful. Several studies have shown that free radicals and oxidants such as hydrogen peroxide can cause cell damage.

At the same time, these same free radicals and oxidants have crucial roles to play in normal functioning of cells. The research team found that oxidants such as hydrogen peroxide create a bond between two amino acids. This bond then activates PKG, causing a lowering of blood pressure.

Dr. Eaton said, “The research could lead to the development of drugs which activate this new pathway.” He and his team now plan to study how this new found pathway affects the events that cause a heart attack.

Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, which funded the research said, “This research is exciting. Firstly, the team’s novel discovery opens up opportunities for the design of new drugs to combat high blood pressure.”

“Secondly, the mechanism provides new insights into how oxidant stress affects cells and tissues. Oxidant stress not only alters blood flow, but also affects the heart’s ability to contract and is involved in a wide variety of inflammatory conditions,” he said.

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